Macdonald Lab

Genetics & Genomics




Research in the Macdonald Lab is directed towards understanding the genetic basis of phenotypic variation. The genetic control of complex traits - those influenced by numerous genetic loci and environmental factors - is poorly understood. This is of great concern because many traits of medical, agricultural, and ecological importance appear to be complex. We are actively engaged in experiments that seek to identify and characterize the precise genetic polymorphisms that contribute to trait variation both within and between species. Our work combines the powerful genetic and molecular tools available for the Drosophila model system with a variety of genomic and bioinformatic approaches. By elucidating the molecular genetic basis of polygenic traits in a model system, we hope to provide a general framework for understanding complex trait variation.

linkage disequilibrium plot recombinant chromosomes for mapping likelihood profile bristle number distribution

4peaks DNA sequence trace genotyping clusters Drosophila sechellia male genital arch female Drosophila melanogaster


Contact

Department of Molecular Biosciences
University of Kansas
1030 Haworth Hall
1200 Sunnyside Avenue
Lawrence
KS 66045

office/lab phone: 785-864-5362
fax: 785-864-5321
email: sjmac@ku.edu

Site info

© 2008 Stuart Macdonald. Adapted from an original design by Andreas Viklund
Last updated July 2, 2008 by Stuart Macdonald

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